Iranian Chemical Science and Technologies Association International Journal of New Chemistry 2645-7237 12 4 2025 03 01 Advances in Green Chemistry: Sustainable Approaches in Organic Synthesis 726 737 719174 10.22034/ijnc.2025.719174 EN Mohammad Kohansal * Department of Chemistry, Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran, Iran. Journal Article 2024 12 22 <span style="font-size: 11.0pt; line-height: 150%; font-weight: normal;">Green chemistry has emerged as a transformative approach to addressing the pressing environmental challenges posed by traditional chemical processes. This review paper, titled "Advances in Green Chemistry: Sustainable Approaches in Organic Synthesis," explores the latest innovations and methodologies that align with the principles of sustainability and environmental stewardship. The field of organic synthesis, a cornerstone of chemical science, has historically relied on resource-intensive and hazardous processes. However, recent advancements have introduced eco-friendly alternatives that minimize waste, reduce energy consumption, and eliminate the use of toxic reagents. This paper highlights key developments such as catalysis-driven transformations, the use of renewable feedstocks, solvent-free and aqueous-phase reactions, and the integration of green technologies like flow chemistry and biocatalysis. Additionally, it examines the role of computational tools and machine learning in optimizing reaction conditions to enhance efficiency and sustainability. By providing a comprehensive overview of these advancements, this review underscores the critical importance of green chemistry in fostering a more sustainable future for organic synthesis while addressing global environmental and economic concerns. The paper also identifies current challenges and potential avenues for future research, emphasizing the need for interdisciplinary collaboration to further revolutionize the field.</span> https://www.ijnc.ir/article_719174_7e6d704eae55f560a85046d7e0724c66.pdf