Iranian Chemical Science and Technologies Association International Journal of New Chemistry 2645-7237 12 5 2025 04 01 Superoxide Dismutase Inhibitors as Cancer Chemopreventive Agents: A New Survey 1029 1035 722918 10.22034/ijnc.2025.722918 EN Mohammad Mahboubi-Rabbani Department of Pharmaceutical Chemistry, School of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Atefeh Jozian Department of Pharmaceutical Chemistry, School of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Gita Faraji Department of Pharmaceutical Chemistry, School of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Sana Khatami Department of Pharmaceutical Chemistry, School of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Kiana Ravanshad Department of Pharmaceutical Chemistry, School of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Maryam Bayanati Department of Food Technology Research, National Nutrition, and Food Technology Research Institute/Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Journal Article 2025 04 20 <span style="font-size: 11.0pt; line-height: 150%; font-weight: normal;">Reactive oxygen species (ROS) are important factors to carcinogenesis, serving as both initiators and promoters of tumor growth. Superoxide dismutases (SODs), a kind of antioxidant enzyme, regulate ROS levels by converting superoxide anions into hydrogen peroxide. While SODs have generally served protective roles, current research has revealed a paradoxical involvement in cancer cell survival and resistance to treatment. This review presents a complete overview of current understanding about SOD inhibitors and their potential as cancer chemopreventive medicines, with a focus on processes, molecular targets, and treatment methods. Eighteen references are mentioned to lay a solid basis for future study in this promising field of cancer.</span> https://www.ijnc.ir/article_722918_bd5b69baeb0bee8558d7f6e078708603.pdf