Document Type : Research Paper
Authors
1 Associate Professor of Anesthesiology, Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Anesthesiologist, Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
Introduction: Hypertension usually begins 5 seconds after intubation and peaks within 1 to 2 minutes, returning to baseline after 5 to 10 minutes. Due to the importance of this issue in this study, we aimed to investigate the effect of fentanyl and sufentanil on hemodynamic responses during laryngoscopy and intubation in patients undergoing Coronary-Artery-Bypass-Graft (CABG) surgery.
Material and Methods: This prospective descriptive study was performed during 2018 in Shahid Madani Hospital (Tabriz University of Medical Sciences) with the participation of 40 patients undergoing CABG surgery. Patients were injected with fentanyl or sufentanil before intubation and after 2 minutes of intubation. The response of blood pressure (systolic and diastolic) and HR to intubation were measured between the two groups.
Results: The mean rate of change of the two groups was analyzed using repeated measures analysis of variance, which generally shows significant changes in the rate of change in HR per minute (p-value = 0.0001). Also, there is no statistically significant difference in the rate of change in HR per minute between the two groups (p-value = 0.758) and it can be said that the two drugs did not have different effects.
Conclusion: In general, no statistically significant differences were observed between the two drug groups. In fact, although both fentanyl and sufentanil modulated hemodynamic changes due to the cardiovascular response to intubation, no significant difference was observed between them in terms of drug effect.
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- AA Asgharinezhad, N Jalilian, H Ebrahimzadeh, Z Panjali, A simple and fast method based on new magnetic ion imprinted polymer nanoparticles for the selective extraction of Ni (II) ions in different food samples. RSC Adv, 5,45510–45519(2015)
- R Ahmadi, MK Karimi Raja, Investigation of Adsorption Enthalpy of Prolin on the Surface of Graphene with and without Si: A DFT Study, International Journal of New Chemistry, 2 ,3, 50-54(2015)
- E Tahmasebi, Y Yamini, Polythiophene-coated Fe3O4 nanoparticles as a selective adsorbent for magnetic solid-phase extraction of silver(I), gold (III), copper (II) and palladium (II). Microchim Acta, 181,543–551 (2014)
- Y Cui, S Liu, K Wei, Y Liu, Z HuMagnetic, solid-phase extraction of trace-level mercury (II) ions using magnetic coreshell nanoparticlesmodified with thiourea-derived chelating agents. Microchim Acta, 182,1337–1344 (2015)
- A Mehdinia, Z Shoormeij, A Jabbari, Trace determination of lead (II) ions by using a magnetic nanocomposite of the type Fe3O4/ TiO2/PPy as a sorbent, and FAAS for quantitation. Microchim Acta, 184,1529–1537(2017)
- QL Li, LL Wang, X Wang, ML Wang, RS Zhao, Magnetic metal-organic nanotubes: an adsorbent for magnetic solid-phase extraction of polychlorinated biphenyls from environmental and biological samples. J Chromatogr A, 1449,39–47(2016)
- Y Yang, X Ma, F Feng, X Dang, J Huang, H Chen, Magnetic solid-phase extraction of triclosan using core-shell Fe3O4@MIL-100 magnetic nanoparticles, and its determination by HPLC with UV detection. Microchim Acta, 183,2467–2472 (2016)
- M Kolaei, K Dashtian, Z Rafiee, M Ghaedi, Ultrasonicassisted magnetic solid phase extraction of morphine in urine samples by new imprinted polymer-supported on MWCNT- Fe3O4-NPs: central composite design optimization. Ultrason Sonochem, 33,240–248(2016)
- J Liu, Z Zhao, P Shao, F Cui, Activation of peroxy monosulfate with magnetic Fe3O4-MnO2 core-shell nanocomposites for 4-chlorophenol degradation. Chem Eng J, 262,854–861(2015)
- P Rocío-Bautista, I Pacheco-Fernández, J Pasán, V Pino, Are metal-organic frameworks able to provide a new generation of solid-phase microextraction coatings?-a review. Anal Chim Acta, 939,26–41(2016)
- F Maya, CP Cabello, RM Frizzarin, JM Estela, GT Palomino, V Cerdà, Magnetic solid-phase extraction using metal-organic frameworks (MOFs) and their derived carbons. TrAC, Trends Anal Chem, 90,142–152 (2017)
- K Leng, Y Sun, X Li, S Sun, W Xu Rapid, synthesis of metal–organic frameworks MIL-101 (Cr) without the addition of solvent and hydrofluoric acid. Cryst Growth Des, 16,1168–1171 (2016)
- LB Escudero, RG Wuilloud, RA Olsina, Sensitive determination of thallium species in drinking and natural water by ionic liquid assisted ion-pairing liquid-liquid microextraction and inductively coupled plasma mass spectrometry. J HazardMater, 244-245,380–386 (2013).
- EA Afshar, MA Taher, H Fazelirad, Ultra-trace determination of thallium (I) using a nanocomposite consisting of magnetite, halloysite nanotubes and dibenzo-18-crown-6 for preconcentration prior to its quantitation by ET-AAS. Microchim Acta, 184,791–797 (2017).
- MJ Baxter, HM Crews, MJ Dennis, I Goodall, D Anderson, The determination of the authenticity of wine from its trace element composition. Food Chem, 60,443–450 (1997).
- S Nazari, A Mehri, AS Hassannia, Fe3O4-modified grapheme oxide as a sorbent for sequential magnetic solid phase extraction and dispersive liquid phase microextraction of thallium. Microchim Acta, 184,3239–3246 (2017).
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