The effect of magnesium sulfate(MG-Sulfate) infusion in the operating room on analgesia after hysterectomy in women with cancer

Document Type : Research Paper

Authors

1 Assistant Professor of Surgery, Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2 2. Ali Reza Naseri: Assistant Professor of Radiotherapy, Department of Radiology, Rahat Breath and Sleep Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

After major surgery, with the onset of acute pain, clinical use of magnesium can reduce postoperative pain by blocking the central sensation of pain by blocking NMDA receptors. The aim of this study was to evaluate the effect of MG-Sulfate infusion in the operating room on analgesia after hysterectomy in women with cancer. In this prospective cross-sectional study, 40 candidates for hysterectomy (due to cancer) were evaluated. Magnesium group (M) 50 mg / kg IV MG-Sulfate in 100 cc normal saline 0.9% and control group (C) 100 cc normal saline 0.9% after intubation and their pain intensity was measured by VAS. Finally, a comparison was made between the two groups. There is no statistically significant change in the amount of pain at rest between the two groups (p-value=0.925) and it can be said that the two drugs did not have different effects. The mean amount of pain changes in cough condition was examined using repeated measures analysis of variance, which showed that the age variable had no statistically significant effect on changes in pain during cough (p-value = 0.925). Administration of MG-Sulfate at a dose of 50 mg / kg has no effect on pain intensity and drug dose after hysterectomy (due to cancer) and also changes systolic and diastolic blood pressure and arterial blood oxygen saturation during and after surgery. This does not apply to the control group and only causes a significant increase in heart rate compared to the control group at the end of the operation.

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  1. A Mehdinia, Z Shoormeij, A Jabbari, Trace determination of lead (II) ions by using a magnetic nanocomposite of the type Fe3O4/ TiO2/PPy as a sorbent, and FAAS for quantitation. Microchim Acta, 184,1529–1537(2017)
  2. QL Li, LL Wang, X Wang, ML Wang, RS Zhao, Magnetic metal-organic nanotubes: an adsorbent for magnetic solid-phase extraction of polychlorinated biphenyls from environmental and biological samples. J Chromatogr A, 1449,39–47(2016)
  3. Y Yang, X Ma, F Feng, X Dang, J Huang, H Chen, Magnetic solid-phase extraction of triclosan using core-shell Fe3O4@MIL-100 magnetic nanoparticles, and its determination by HPLC with UV detection. Microchim Acta, 183,2467–2472 (2016)
  4. M Kolaei, K Dashtian, Z Rafiee, M Ghaedi, Ultrasonicassisted magnetic solid phase extraction of morphine in urine samples by new imprinted polymer-supported on MWCNT- Fe3O4-NPs: central composite design optimization. Ultrason Sonochem, 33,240–248(2016)
  5. J Liu, Z Zhao, P Shao, F Cui, Activation of peroxy monosulfate with magnetic Fe3O4-MnO2 core-shell nanocomposites for 4-chlorophenol degradation. Chem Eng J, 262,854–861(2015)
  6. P Rocío-Bautista, I Pacheco-Fernández, J Pasán, V Pino, are metal-organic frameworks able to provide a new generation of solid-phase microextraction coatings? a review. Anal Chim Acta, 939,26–41(2016)
  7. F Maya, CP Cabello, RM Frizzarin, JM Estela, GT Palomino, V Cerdà, Magnetic solid-phase extraction using metal-organic frameworks (MOFs) and their derived carbons. TrAC, Trends Anal Chem, 90,142–152 (2017)
  8. K Leng, Y Sun, X Li, S Sun, W Xu Rapid, synthesis of metal–organic frameworks MIL-101 (Cr) without the addition of solvent and hydrofluoric acid. Cryst Growth Des, 16,1168–1171 (2016)
  9. LB Escudero, RG Wuilloud, RA Olsina, Sensitive determination of thallium species in drinking and natural water by ionic liquid assisted ion-pairing liquid-liquid microextraction and inductively coupled plasma mass spectrometry. J HazardMater, 244-245,380–386(2013)
  10. EA Afshar, MA Taher, H Fazelirad, Ultra-trace determination of thallium (I) using a nanocomposite consisting of magnetite, halloysite nanotubes and dibenzo-18-crown-6 for preconcentration prior to its quantitation by ET-AAS. Microchim Acta, 184,791–797(2017)
  11. MJ Baxter, HM Crews, MJ Dennis, I Goodall, D Anderson, The determination of the authenticity of wine from its trace element composition. Food Chem, 60,443–450(1997)
  12. S Nazari, A Mehri, AS Hassannia, Fe3O4-modified grapheme oxide as a sorbent for sequential magnetic solid phase extraction and dispersive liquid phase microextraction of thallium. Microchim Acta, 184,3239–3246(2017)
  13. 26 H Kalantari, M Manoochehri, A nanocomposite consisting of MIL-101 (Cr) and functionalized magnetite nanoparticles for extraction and determination of selenium (IV) and selenium (VI).Microchim Acta, 185,196(2018)
  14. EA Afshar, MA Taher, H Fazelirad, Microchim Acta, 184,791–797(2017)
  15. S Nazari, A Mehri, AS Hassannia, Microchim Acta, 184, 3239–3246(2017)
  16. S Dadfarnia, T Assadollahi, AH Shabani, J Hazard Mater, 148,446–452(2007)
  17. A Darroudi, MH Arbab Zavar, M Chamsaz, G Zohuri, N Ashraf, Anal Methods, 4, 3798–3803(2012)
  18. RA Gil, PH Pacheco, P Smichowski, RA Olsina, LD Martinez, ,Microchim Acta, 167,187–193. (2009)
  19. M Chamsaz, MH Arbab-Zavar, A Darroudi, T Salehi,J Hazard Mater, 167,597–601. (2009)
  20. MH Arbab-Zavar, M Chamsaz, G Zohuri, A Darroudi, J Hazard Mater, 185, 38–43. (2011)
  21. S Asadpour, M Chamsaz, MH Entezari, MJ Haron, N Ghows, Arab J Chem, 9, S1833-S1839. (2016)