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Document Type : Research Paper


Associate Professor of Otorhinolaryngology, Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


Introduction: Considering that the prevalence of cleft palate anomalies depends on the geographical area and race and so far no epidemiological study has been conducted in Sari, in this study we decided to investigate the prevalence of cleft lip with or without cleft palate and related factors. We will deal with it among newborns born in the city of Tabriz.

Material and Methods: This descriptive-analytical study was conducted during the years 2015-2020 in the hospitals of Tabriz University of Medical Sciences. The total case of newborns was examined for cleft lip and palate and risk factors were obtained.

Results: 80 cases of cleft lip/cleft lip and palate were found. Most mothers have no history of experiencing these conditions. Also, among the 25 cases that mentioned the history of drug use in the first trimester of pregnancy; Levothyroxine (6 cases), insulin drug (4 cases), calcium supplement drug (4 cases) and residues (11 cases) as a combination of these drugs with several other drugs including antibiotics and ranitidine Was reported.

Conclusion: The findings of the present study indicate that the overall prevalence of oral clefts among the study population in the three mentioned medical centers was 1.2 per 1,000 births and mainly occurred unilaterally.


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