ISC, DOAJ, CAS, Google Scholar......

Document Type : Research Paper


Education Department, District 1, Tehran, Iran.


In the combination of 5-fluorophenyl-1, 3, 7, 9-tetra methyl pyrido [2, 3, d, d, 5, 6 di pyrimidine -2, 4, 6, and 8 tetron, there are 4 rings, respectively, ring that is attached to the halogen ring A and, respectively, a ring The lower and the right to the left of the ring A are called C, B, and D. Calculations and studies show that the amount of aromatics in halogen-ring A in all cases has the highest amount. In the B and D loop, the predicted aromaticity level is low and close to zero, and there is a reduction in aromatics in the C loop than the A ring. In another stage of the study, with the replacement of the halogen ring A from F to I, the following trend was observed. In ring A, when halogens were changed, the increase in aromaticity in halogenated compounds was as follows:  F> Cl> Br> I.


[1] C. R. Zhang, H. S. Chen, G. H. Wang,Chem. Res. Chinese, 20, 640 (2004).
[2] R. Ahmadi, K. Kalateh, V. Amani, Acta. Crystallogr. E., 66, m959 (2010).
[3] H. Cheng, J. Feng, A. Ren, J. Liu, Acta Chim. Sin., 60, 830 (2002).
[4] Y. Sun, X. Chen, L. Sun, X. Guo, W.Lu, Chem. Phys. Lett. , 381, 397 (2003).
[5] Z. Khoshtarkib, A. Ebadi, R. Alizadeh, R. Ahmadi, V. Amani, Acta. Crystallogr. E., 65, m739 (2009).
[6] S. Gunasekaran, R. A. Balaji, S.Kumeresan, G. Anand, S. Srinivasan, Can. J.Anal. Sci. Spectrosc., 53, 149 (2008).
[7] B. Kosar, C. Albayrak, Spectrochim.Acta A, 78, 160 (2011).
[8] R. Alizadeh, K. Kalateh, A. Ebadi, R. Ahmadi, V. Amani, Acta. Crystallogr. E., 65, m1250 (2009).
[9] R. G. Pearson, Chemical Hardness,Wiley-VCH: Oxford, (1997).
[10] R. G. Parr, W. Yang, Density-Functional Theory of Atoms and Molecules,Oxford University Press: New York, (1989).
[11] R. G. Parr, L. Szentpaly, S. Liu, J. Am.Chem. Soc., 121, 1922 (1999).
[12] C. Hulme, V. Gore, Curr. Med. Chem., 10,51 (2003).
[13] M. Kidwai, P. Mothsra, V. Bansal, R.K.Somvanshi, A.S. Ethayathulla, S. Dey, T.P.Singh, J. Mol. Catal. A., 265, 177 (2007).
[14] R.Tayebee, M.Ghadamgahi, American J.Org. Chem., 2 (1), 25 ( 2012)
[15] E. Fereyduni, M. Kamaee, R. Soleymani, R. Ahmadi, J. Theor. Comput. Chem., 11, 1331 (2012)
[16] R. Liebi, R.Randte, H. Mildenberger, K.Bauer, and H. Bieringer, Chem. Abst., 108, 6018 (1987).
[17] S.E. Wolkenberg , D.D. Wisnosk, W.B.Leister, Y. Wang, Z. Zhao, and C.W. Lindsley, Org. Let., 6, 1453 (2004).
[18] A.F. Ppozherskii, A.T. Soldalenkov, and A.R. Katritzky, Heterocycle in Life Society (New York: Wiley), 179 (1997).
[19] J.G. Lombardino, and E.H. Wiseman, J.Med. Chem., 17, 1182 (1974).
[20] R. Ahmadi, R. Soleymani, J. Phys. Theor. Chem., 10, 201 (2013).
[21] W. Xu, K.A. Abboud, I. Ghiviriga, W.R.Dolbier, M. Rapp, S.F. Wnuk, Org. Lett., 8,
5549 (2006).