Document Type : Research Paper

Authors

• M.Sathiya Murugesan
• Guhanathan Selvam

PG & Research Department of Chemistry, Muthurangam Government Arts College (Autonomous), Vellore-632 002, TN, India

Abstract

Nitrogen containing hetero cyclic compounds constitute the interior structure of a number of biologically attracted compounds against bacteria and fungi. The synthesis of carbazole derivatives have been desire due to their importance in medicinal field. Enhanced approach of Fischer’s synthesis followed by bromoacetylation have been used to synthesis four different carbazole derivatives, namely 1-bromo-2-(6-bromo-1,2,3,4-tetrahydro-9H-carbazol-1-yl) ethanone, 1-bromo-2-(5-bromo-1,2,3-trihydrocyclopenta[b]indole-1-yl) ethanone. The synthesized compounds were identified and confirmed using spectral techniques Viz, FTIR, 1H NMR, 13C NMR, MASS Spectroscopy. Antibacterial evaluation of synthesized compounds found to have pronozed antibacterial activity.Nitrogen containing hetero cyclic compounds constitute the interior structure of a number of biologically attracted compounds against bacteria and fungi. The synthesis of carbazole derivatives have been desire due to their importance in medicinal field. Enhanced approach of Fischer’s synthesis followed by bromoacetylation have been used to synthesis four different carbazole derivatives, namely 1-bromo-2-(6-bromo-1,2,3,4-tetrahydro-9H-carbazol-1-yl) ethanone, 1-bromo-2-(5-bromo-1,2,3-trihydrocyclopenta[b]indole-1-yl) ethanone. The synthesized compounds were identified and confirmed using spectral techniques Viz, FTIR, 1H NMR, 13C NMR, MASS Spectroscopy. Antibacterial evaluation of synthesized compounds found to have pronozed antibacterial activity.

Keywords

• Bromoacetyl bromide
• Ciprofloxacin
• novel carbazole