Trans Aconitic acid based biopolymeric hydrogel with Antibacterial, Antioxidant and Anticancer property

Subramani, Selvi; Selvam, Guhanathan

doi:10.22034/ijnc.2024.2009601.1355

Document Type : Research Paper

Authors

Selvi Subramani ¹
Guhanathan Selvam ²

¹ PG & Research Department of Chemistry, Muthurangam Government Arts College (Autonomous), Vellore-632 002, Tamil nadu, India.

² PG Assistant in Chemistry, Government Higher Secondary School, Madanur-635804, Tamil Nadu, India

https://doi.org/10.22034/ijnc.2024.2009601.1355

Abstract

A novel biopolymeric hydrogels have been synthesized by two step process using trans aconitic acid, ethylene glycol and glutamic acid without a cross linker by organic solventless approach with different monomer ratios in a eco friendly manner. The nature of bonding and structural identification of biopolymeri hydrogels were characterized by analytical techniques like FT-IR. The hydrogel shows a pH sensitive swelling behaviour with increased swelling in acidic media followed by gradual decreased in basic media. The thermogram (TGA) of the hydrogel shows two stage of degradation. The obtained hydrogels were also subjected to antibacterial activity against gram positive S.aureus and gram negative E.Coli by using zone inhibition method, and antioxidant activity by DPPH radical assay at different concentration compared with the standard Ascorbic acid and anticancer activity by MTT assay using HT29 colan cancer cell line. The results exhibit excellent antibacterial, antioxidant and anticancer property with respect to their standards respectively.

Keywords

Main Subjects

Applied Chemistry

References

[1] Z. Fan, B. Liu, J. Wang, S. Zhang, Q. Lin, P. Gong, L. Ma, S. Yang, Adv. Funct. Mater., 24, 3933–3943 (2014).

[2] X. Zhao, B. Guo, H. Wu, Y. Liang, P.X. Ma, Nat. Commun., 9, 2784 (2018).

[3] B. Guo, P.X. Ma, Biomacromolecules., 19, 1764–1782 (2018).

[4] K. H. Syed Gulrez, Saphwan Al-Assaf, Glyn O Phillips, Progress in Molecular and Environmental Bioengineering (2011).

[5] G. Chitra, D.S. Franklin, S. Sudarsan, M. Sakthivel and S. Guhanathan, Int. J. Biol. Macromol., 95, 363-375, (2017).

[6] P. R. Chandrana, N. Sandhyarani, RSC Adv., 4. 44922-44929 (2014).

[7] P. Laxmi, B.Monica, B.Ashish, S. Veena, S.Vinay, Iran. Polym., 25, 919–931 (2016).

[8] V. Lobo, A. Patil, A. Phatak, N. Chandra, Pharmacogn. Rev., 4, 118–126 (2010).

[9] F. Murad, Angew. Chem. Int. Ed., 38, 13–14 (1999).

[10] T.A. Heinrich, R.S. da Silva, K.M. Miranda, C.H. Switzer, D.A. Wink, J.M. Fukuto, Br. J. Pharmacol., 169, 1417–1429 (2013).

[11] J. Qu et al.. Chem. Eng. J., 362, 548–560 (2019).

[12] J. Maria, Molecules., 17, 14022-14036, (2012).

[13] O. Dilvani Santos, Parasitol Res., 103,1–10 (2008).

[14] H. A. Cranston, Manufacture of aconitic acid., US Patent 2,566,172. (1951).

[15] H. A. Cranston, Manufacture of aconitic acid., US Patent 2,727,066. (1955).

[16] A. Petit, J.Wu-Tiu-Yen, E.Pislor, P. Pontalier, J. Albet, W.Hoareau, L.Corcodel,. FR patent EP2921471 (A1), (2015).

[17] G. Malmary, J. Albet, A. Putranto, H. Hanine, J. Molinier, J. chem. technol. biotechnol., 75(12), 1169–1173 (2000).

[18] S.Kar, K.Kar, PK.Bhattacharya, D.K. Ghosh, Antimicrob Agents Chemother., 37(11), 2459–2465 (1993)

[19] W. Piang-Siong, P.d. Caro, A. Marvilliers, X. Chasseray, B.Payet, A.S.C. Sing, B. Illien, Food Chemistry., (2016).

[20] S. Sudarsan, M.S Selvi, G. Chitra, M. Sakthivel, D.S. Franklin, S.Guhanathan, Polym-plast tech mat., 1-21 (2020).

[21] Z. Zhang, Z. Cheng, T. Zhao, J. Agri. Food Chem., 62, 8867-8888 (2014).

[22] J. Zuber, I. Radtke, T.S Pardee, Z. Zhao, A.R Rappaport, W Luo, M.E. Mc Currach, M.M. Yang, M.E. Dolan, S.C. Kogan, Gene. Developm., 23, 877-888 (2009).

[23] Mehmet Arslan.; Tugce Nihal Gevrek.; Rana Sanyal.; Amitav Sanyal. Europ. Polym. 62,426-434, (2015).

[24] S.Dutta, S.Ray, K.Nagarajan, Der Pharm. Chem., 3(2), 263–272 (2011).

[25] Viviane Costa de Souza , carbohydr poly, 202,11-19 (2018).

[26] I.L. Shih, Y.T., Van, M.H., Shen. Mini Rev. Med. Chem., 4(2), 179–188 (2004).

[27] B.M. Oaks, K.W. Dodd, C.L. Meinhold, L. Jiao, T.R. Church, R.Z. Stolzenberg-Solomon, Am. J. Clin. Nutr., 91(2), 449–455 (2010).

[28] E., Giovannucci, M.J., Stampfer, G.A., Colditz, D.J., Hunter, C., Fuchs, B.A., Rosner, F.E., Speizer, W.C., Willett, Ann. Intern. Med., 129(7), 517–524 (1998).

[29] S.S. Percival, J.F. Bukowski, J. Milner, J. Nutr., 138(1), 1–4 (2008).

[30] S. Sudarsan, DS. Franklin, M. Sakthivel, S.Guhanathan, Carbohydr Polym., 148, 206–215 (2016).

[31] S. Sudarsan, DS. Franklin, M. Sakthivel, S.Guhanathan, Jour Polym Environ., 26, 3773–3784 (2018).

[32] G. Chitra, D.S. Franklin, S. Sudarsan, M. Sakthivel, S.Guhanathan, Polym. Eng. Sci., 58(12), 2133-2142 9 (2018).

[33] M. Sakthivel, D.S. Franklin, S. Sudarson, G. Chitra, S. Guhanathan, Mat. Sci Eng., 75, 517-525(2017).

[34] D.S. Franklin, S. Guhanathan, Ecotoxicol. Environ. Saf., 121, 80–86, (2015).

[35] G.Chitra, Asian J. Chem., 29(12), 2647-2650, (2017).

[36] M. Sadeghi, B. Heidari, Materials., 4, 543-552, (2011).

[37] I. Asmarandei, G. Fundueanu, M. Cristea, V. Harabagiu, J. Polym. Res., 20, 293–300, (2013).

[38] V.B. Bueno, R. Bentini, L.H. Catalane, D.F. Siqueira Petri, Polym., 92, 1091–1099, (2013).

[39] D.S. Franklin, S. Guhanathan, J. Appl. Polym. Sci., 132, 41403, (2015).

[40] H.E. Guanghua, Z. Hua, X. Fuliang, J. Wuhan, Uni Technol Mate., 23(6), 816–820, (2008).

[41] F.M. Alminderej, Molecules., 24(20), 3738, (2019).

[42] H. Tashakkorian et al. / Data in brief 28 (2020).

[43] S. Jana, M.K. Trivedi, R.M. Tallapragada, A. Branton, D. Trivedi, G. Nayak, R. Mishra, Pharm. Anal. Acta., 6, 10. (2015).

[44] Pelin Yilmaz, Elif ozturk Er, Sezgin Bakirdere, Kutlulgen, Belma ozbek, J. mater. Res technol., 8(6), 5201–5216 (2019).

[45] Nagaraja Naik, Honnaiah Vijay Kumar, Salakatte Thammaiah Harini, Eur. J.Chem., 2, 337–341, (2011).

[46] M. Pulat, H. Eksi and U. Abbasoglu,J. Biomater, Sci. Polym. Ed., 19(2), P193–205, (2008).

[47] M. M. Babic, M. Katarina, S. J. J. Vukovic, B. D. Boz, Z. Sladjana, M. Filipovic and S. L. Tomic,J. Mater. Sci., 50, 906–922, (2015).

[48] Youdim KA, Joseph JA, Free Radic Biol Mde. (2001).

[49] R.M. Patel and N.J. Patel, J. Adv. Pharm. Educ. Res., 1, 52 (2011).

[50] Renata Dobrucka, J Inorg Organomet Polym Mater., 28, 812–819 (2018).

[51] Satyajit Dutta Supratim Ray NagarajanSaudi Pharmaceutical Journal 21, 337–343 (2013).

[52] S. Wang, X. Cao, M. Shen, R. Guo, I. Bányal, X. Shi, Colloids Surf B., 89, 254–264 (2012).

[53] K. Krukiewicz, J.K. Zak., Mater. Sci. Eng. C., 62, 927–942 (2016).

[54] G. Chitra, M. Sakthivel, D.S. Franklin, S. Sudarsan, M.S. Selvi, S. Guhanathan, J.Poly.Mat. and Poly. Bioma., 26, 728-738(2019).

International Journal of New Chemistry

Trans Aconitic acid based biopolymeric hydrogel with Antibacterial, Antioxidant and Anticancer property

References

References

Volume 11, Issue 3
February 2024
Pages 226-242

Trans Aconitic acid based biopolymeric hydrogel with Antibacterial, Antioxidant and Anticancer property

References

References

Volume 11, Issue 3February 2024Pages 226-242

Volume 11, Issue 3
February 2024
Pages 226-242