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Selvam, G., MURUGESAN, M., Uthaikumar, S. (2019). Investigation of dibromo and N-bromoacetyl derivatives of [b] carbazole-synthesis and antibacterial evaluation. International Journal of New Chemistry, 6(2), 66-75. doi: 10.22034/ijnc.2019.33862
Guhanathan Selvam; M.SATHIYA MURUGESAN; sangeetha Uthaikumar. "Investigation of dibromo and N-bromoacetyl derivatives of [b] carbazole-synthesis and antibacterial evaluation". International Journal of New Chemistry, 6, 2, 2019, 66-75. doi: 10.22034/ijnc.2019.33862
Selvam, G., MURUGESAN, M., Uthaikumar, S. (2019). 'Investigation of dibromo and N-bromoacetyl derivatives of [b] carbazole-synthesis and antibacterial evaluation', International Journal of New Chemistry, 6(2), pp. 66-75. doi: 10.22034/ijnc.2019.33862
Selvam, G., MURUGESAN, M., Uthaikumar, S. Investigation of dibromo and N-bromoacetyl derivatives of [b] carbazole-synthesis and antibacterial evaluation. International Journal of New Chemistry, 2019; 6(2): 66-75. doi: 10.22034/ijnc.2019.33862

Investigation of dibromo and N-bromoacetyl derivatives of [b] carbazole-synthesis and antibacterial evaluation

Article 1, Volume 6, Issue 2, Spring 2019, Page 66-75  XML PDF (865.57 K)
Document Type: Research Paper
DOI: 10.22034/ijnc.2019.33862
Authors
Guhanathan Selvam email orcid ; M.SATHIYA MURUGESANorcid ; sangeetha Uthaikumarorcid
PG and Reseach Department of Chemistry Muthurangam Government Arts College Vellore -632 002
Abstract
The synthesis, structure and biological activity of carbazole compounds has been long focus of research interests in the field of medicinal chemistry. 5,8-dibromo-5,6-dihydro(3,2-a)carbazole A have prepared in good yield by a free radical bromination reaction of 8-bromo-5,6-dihydro9(3,2-a)carbazole with N-bromosuccinimide in carbontetrachloride at ambient temperature.. Compound 2 have prepared by free radical brimination method in carbontetrachloride at 40°C. Synthesis of compound C have carried out by free radical bromination with 5-bromo-1,2,3,4-tetrahydrocyclopenta(b)indole as reactant, in dichloromethane at ambient temperature. Compound 2, 4, and 6 were synthesized by N-bromoacetylation method using bromoacetylbromide as reactant. All the synthesized compounds were characterized and confirmed by various instrumental techniques Viz, UV-visible, FTIR, 1H NMR, 13C NMR and Mass spectroscopy. All the synthesized compounds were subjected to the antibacterial evaluation with standard Ciprofloxacin. The results showed that the synthesized compounds exhibit excellent antibacterial activity.
Keywords
N-bromosuccinimide; bromoacetylbromide; carbontetrachloride; Carbazole deivative
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