Voltammetric sensor for Nifedipine at woolen ball-shaped nanostructure modified glassy carbon electrode

Foroughi, Mohammad Mehdi; Jahani, Shohreh; Rashidi, Soroush

doi:10.22034/ijnc.2024.2022678.1376

Voltammetric sensor for Nifedipine at woolen ball-shaped nanostructure modified glassy carbon electrode

Document Type : Research Paper

Authors

Mohammad Mehdi Foroughi ¹

Shohreh Jahani ²

Soroush Rashidi ³

¹ Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran

² Bam University of Medical Sciences, Bam, Iran

³ Department of Civil Engineering, Islamic Azad University, Kerman, Iran

https://doi.org/10.22034/ijnc.2024.2022678.1376

Abstract

This work faces this challenge by the development of a novel electrochemical sensor via modifying a glassy carbon electrode (GCE) with woolen ball-shaped La3+/TiO2 nanostructure (WB-S La3+/TiO2-NS) for the detection of Nifedipine (NFP). Different characterization techniques indicate the successful synthesis of desired composite materials. Modified electrode exhibited higher peak current than the bare GCE, with excellent electrocatalytic ability to oxidize NFP, due to its higher conductivity, catalytic effect and synergistic effects between La3+ and TiO2 nanostructure. Under optimized condition, differential pulse voltammograms (DPV) demonstrate that the oxidation peak current was proportional to its concentration in the range of 0.001–500.0 µM (R2 = 0.9997) and low detection limit (0.43 nM). In addition, the modified electrode affirms good stability and reproducibility, making it simple, cost effective with high sensitivity. The results confirmed that making a composite is a key strategy for improving the physicochemical properties of TiO2 nanostructure and that modifying electrode surfaces with novel composites can enhance the detection of NFP.

Keywords

Nifedipine

Voltammetry

Lanthanum

Nanostructure

Titanium dioxide

Subjects

Analytical Chemistry

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