International Journal of New Chemistry
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An Update Comprehensive Review on the Antiviral Activities of Chalcone Analogs

Document Type : Review

Authors

Rozin Moghimi 1
Homayon Jafari Moghadam 1
Fereshteh Talebi 2
Sepideh Abrishami 3
Mohammad Mahboubi-Rabbani 1

1 Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

2 Student Research Committee, Hormozgan University of Medical Science, Bandar Abbas, Iran

3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

https://doi.org/10.22034/ijnc.2024.715382
Abstract
Since ancient times, the world has experienced several viral epidemics, the most recent one was the COVID-19 pandemic. The emergence of new viral infections has led to a need for newer therapeutic approaches that can overcome the limitations of conventional antiviral drugs. Natural open-chain flavonoids called chalcones can be synthesized in laboratories and are present in a variety of plants. Numerous investigations have demonstrated the pharmacological actions of these tiny chemical compounds, which include antiviral, anti-inflammatory, antibacterial, and anticancer properties. This article provides an overview of the antiviral characteristics of chalcones and their derivatives against several human viral infections, with potential use in the COVID-19 pandemic. This article reviews chalcones' work on human viruses such as Hepatitis B and C, Rift Valley fever, Human Immunodeficiency, Influenza, Human Rhinovirus, Herpes Simplex, Dengue, Human CMV, and Venezuelan Equine Encephalitis. This review could lead to the development of chalcone-based antiviral medicines that are both efficacious and versatile.

Keywords

Chalcones
viral infections
COVID-19
HIV
influenza virus
HSV
hepatitis B virus
rhino virus
dengue virus
Subjects
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International Journal of New Chemistry
Volume 12, Issue 4
Winter 2025
Pages 701-725

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