International Journal of New Chemistry
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A Comprehensive Review on the Pharmacology of Tricyclic Antidepressants and their Analytical Methods

Document Type : Review

Author

Ali Behnia

Faculty of Pharmacy, University of Szeged, Eötvös u 6., 6720 Szeged, Hungary

https://doi.org/10.22034/ijnc.2024.715835
Abstract
This review article provides a comprehensive overview of the pharmacology of tricyclic antidepressants (TCAs) and their analytical methods. Tricyclic antidepressants are a class of medications that have been used for decades to treat various mental health conditions, including depression, anxiety, and obsessive-compulsive disorder. The article discusses the pharmacological mechanisms of TCAs, including their effects on neurotransmitter systems such as serotonin, norepinephrine, and dopamine. Additionally, the review covers the pharmacokinetics and pharmacodynamics of TCAs, including their metabolism, distribution, and excretion in the body. Furthermore, the article delves into the analytical methods used to detect and quantify TCAs in biological samples, such as chromatography, mass spectrometry, and immunoassays. The review also explores the challenges and advancements in TCA analysis, including the development of more sensitive and selective analytical techniques. Overall, this review aims to provide a comprehensive understanding of the pharmacology of TCAs and the analytical methods used to study these important medications.

Keywords

Tricyclic antidepressants (TCAs)
Pharmacology
Analytical Techniques
Quality control
Subjects
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International Journal of New Chemistry
Volume 12, Issue 1
Winter 2025
Pages 87-96

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