International Journal of New Chemistry
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Synthesis, Characterization, and Antibacterial Activity of a Copper (II) Complex with N,1-Diphenylmethanimine Schiff Base Ligand

Document Type : Research Paper

Authors

Seyed Jalal Hoseyni
Hediyeh Hatami fard
Mohadeseh Parsaee rad
Zahra Saberi zadeh
Fatemeh Zarafshan
Parmida Firouze

Department of Chemistry, Shams Gonbad higher education institute, Gonbad kavous, Iran

10.22034/ijnc.2025.721220
Abstract
This study focuses on the synthesis, characterization, and biological evaluation of a novel Schiff base ligand, N,1-diphenylmethanimine, derived from the condensation of aniline and benzaldehyde, and its corresponding copper (II) complex. The ligand and metal complex were characterized comprehensively using Fourier Transform Infrared (FT-IR), Proton Nuclear Magnetic Resonance (^1H-NMR), and Carbon-13 Nuclear Magnetic Resonance (^13C-NMR) spectroscopy. The FT-IR data revealed the formation of the C=N functional group and its subsequent shift upon coordination with the copper ion, while ^1H-NMR and ^13C-NMR spectra provided insights into the molecular structure and coordination environment. The antibacterial activity of the synthesized compounds was investigated against Escherichia coli (E. coli) using the disk diffusion method. The results demonstrated that the copper complex exhibited significantly enhanced antibacterial activity compared to the free ligand. This study highlights the potential of Schiff base copper complexes as effective antimicrobial agents, emphasizing their importance in pharmaceutical research.

Keywords

Schiff base ligand
Copper(II) complex
N
1-Diphenylmethanimine
Antibacterial activity
FT-IR spectroscopy
NMR spectroscopy
Subjects
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International Journal of New Chemistry
Volume 11, Issue 4
Winter 2024
Pages 502-509

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