Electrochemical Sensor for Ketoconazole Determination with Molecularly Imprinted Polymer-Carbon Ceramic Electrode (MIP/CCE)

Ershad, Sohrab; Dadmanesh, Somayeh; Hosseinzadeh, Mehdi

doi:10.22034/ijnc.2023.2015078.1363

Document Type : Research Paper

Authors

¹ payame noor university

² Payame Noor University (PNU), P.O BOX 19395-4697, Tehran, Iran

³ Marand Faculty of Technical and Engineering, University of Tabriz, Tabriz, Iran

https://doi.org/10.22034/ijnc.2023.2015078.1363

Abstract

Using a molecularly imprinted polymer (MIP) as a recognition element, a selective voltammetric sensor for ketoconazole (KC) was designed and constructed. MIP was synthesized using methacrylic acid as a functional monomer and KC as a template, and then into the carbon paste electrode as a ketoconazole sensor, was incorporated. A new chemically modified electrode containing MIP compound on the surface of a glassy carbon electrode (GCE) by sol-gel method was obtained. The electrochemical behavior of the resulting modified electrode by cyclic voltammetry method in detail was investigated. The obtained film electrode had very good stability and thus exhibited a good electrocatalytic response for KC oxidation. A sharp catalytic oxidation peak was observed at around 53 mV in the MIP/CCE electrode and GCE, and a small oxidation peaks current at about 63 mV was observed. The diffusion coefficient and transfer coefficient (α) for the electrocatalytic oxidation of KC were also studied under experimental conditions.

Keywords

Main Subjects

Analytical Chemistry

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International Journal of New Chemistry

Electrochemical Sensor for Ketoconazole Determination with Molecularly Imprinted Polymer-Carbon Ceramic Electrode (MIP/CCE)

References

References

Volume 11, Issue 2
January 2024
Pages 113-122

Electrochemical Sensor for Ketoconazole Determination with Molecularly Imprinted Polymer-Carbon Ceramic Electrode (MIP/CCE)

References

References

Volume 11, Issue 2January 2024Pages 113-122

Volume 11, Issue 2
January 2024
Pages 113-122