International Journal of New Chemistry
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Superoxide Dismutase Inhibitors as Cancer Chemopreventive Agents: A New Survey

Document Type : Review

Authors

Mohammad Mahboubi-Rabbani 1
Atefeh Jozian 1
Gita Faraji 1
Sana Khatami 1
Kiana Ravanshad 1
Maryam Bayanati 2

1 Department of Pharmaceutical Chemistry, School of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

2 Department of Food Technology Research, National Nutrition, and Food Technology Research Institute/Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

10.22034/ijnc.2025.722918
Abstract
Reactive oxygen species (ROS) are important factors to carcinogenesis, serving as both initiators and promoters of tumor growth. Superoxide dismutases (SODs), a kind of antioxidant enzyme, regulate ROS levels by converting superoxide anions into hydrogen peroxide. While SODs have generally served protective roles, current research has revealed a paradoxical involvement in cancer cell survival and resistance to treatment. This review presents a complete overview of current understanding about SOD inhibitors and their potential as cancer chemopreventive medicines, with a focus on processes, molecular targets, and treatment methods. Eighteen references are mentioned to lay a solid basis for future study in this promising field of cancer.

Keywords

Reactive Oxygen Species (ROS)
Superoxide Dismutases
Protective Roles
Cancer Cell Survival
Cancer Chemopreventive

Subjects

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International Journal of New Chemistry
Volume 12, Issue 5
Spring 2025
Pages 1029-1035

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